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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac threat components using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person also had polycythemia, doubtless secondary to high-dose testosterone. The patient camsoda/com underwent successful percutaneous intervention of the best coronary artery. Physicians and sufferers ought to pay consideration to the scientific consequences of anabolic steroid abuse.
Unfortunately, the data on the usage of excessive dose anabolic steroids in people are primarily supplied as case stories or small studies that lack adequate control groups. In addition, the data out there in the literature does not account for the steroid sort or dose, as neither could additionally be known. Patients also may be taking concomitant stimulants, corresponding to ephedra, which may confound knowledge and the potential for adverse occasions. It is likely that the frequency of cardiac events is underreported in the medical literature. Supraphysiologic doses of anabolic-androgenic steroids , which embody more than 30 natural and artificial derivatives of testosterone, may cause a wide spectrum of scientific sequalae.
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Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a component of endothelial dysfunction has been proposed, which may contribute to irregular vessel reactivity. However, testosterone in physiologic doses could even be beneficial in sufferers with angina , have greater ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood flow in males with established coronary artery disease .